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With his trust in Octavius restored following their battle with Regent, Peter resumes getting his life back on track while attempting to get Octavius and Max to reconcile. Spider-Man is having great trouble in stopping the slick criminal Slyde. To rectify this, he accepts Octavius' help in taking down Slyde and discovers a connection between the speedster and Beeman Chemicals Corporation. Assisted by Octavius' Octobots, Spider-Man must stop Slyde from using whatever cutting-edge chemicals he has at his disposal to exact his revenge on both the company and New York itself.