Stuart Little.Eleanor and Frederick Little and their young son George are intending an adoption. While George is at school, his parents go to an orphanage where they meet and fall in love with a humanoid mouse named Stuart. Despite misgivings from Mrs. Keeper, they adopt Stuart and take him home. However, Stuart is greeted coldly by George, who refuses to acknowledge the mouse as his brother, and the family cat Snowbell, who is disgusted at having a mouse for a "master". Despite Eleanor and Frederick's intentions, Stuart quickly feels like an outsider in the large Little family, especially when the family's unknowing relatives bring Stuart large presents and George snaps at his family, claiming out loud that Stuart is not his brother. When Stuart admits his feelings of loneliness to his parents, they ask Mrs. Keeper to do some background research on Stuart's biological family. After accidentally stumbling across George's playroom in the basement, Stuart finally bonds with George when they play together and plan to finish George's remote controlled boat, the Wasp, for an upcoming boat race in Central Park. At the same time, however, one of Snowbell's alley cat friends, Monty visits unexpectedly and discovers Stuart. Determined not to have his reputation destroyed, Snowbell meets with Monty's leader, Smokey, a mafia don-like alley cat, and plans to have Stuart removed from the household without harming him.

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